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N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels

N termini of auxiliary β subunits that produce inactivation of large-conductance Ca(2+)-activated K(+) (BK) channels reach their pore-blocking position by first passing through side portals into an antechamber separating the BK pore module and the large C-terminal cytosolic domain. Previous work ind...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Zeng, Xu-Hui, Xia, Xiao-Ming, Lingle, Christopher J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654086/
https://www.ncbi.nlm.nih.gov/pubmed/19237592
http://dx.doi.org/10.1085/jgp.200810079