Matrix Metalloproteinase Proteolysis of the Myelin Basic Protein Isoforms Is a Source of Immunogenic Peptides in Autoimmune Multiple Sclerosis

BACKGROUND: Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The classic MBP isoforms are predominantly expressed in the oli...

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Detalles Bibliográficos
Autores principales: Shiryaev, Sergey A., Savinov, Alexei Y., Cieplak, Piotr, Ratnikov, Boris I., Motamedchaboki, Khatereh, Smith, Jeffrey W., Strongin, Alex Y.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654159/
https://www.ncbi.nlm.nih.gov/pubmed/19300513
http://dx.doi.org/10.1371/journal.pone.0004952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654159/
https://www.ncbi.nlm.nih.gov/pubmed/19300513
http://dx.doi.org/10.1371/journal.pone.0004952

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