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The SCF(Slimb) ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication
Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the mechanisms underlying this block to reduplication are unclear. Genetic analyses have suggested an involvement for Skp/Cullin/F box (SCF)-class ubiquitin ligases in this proc...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654306/ https://www.ncbi.nlm.nih.gov/pubmed/19171756 http://dx.doi.org/10.1083/jcb.200808049 |