Dendritic Cell-Mediated-Immunization with Xenogenic PrP and Adenoviral Vectors Breaks Tolerance and Prolongs Mice Survival against Experimental Scrapie

In prion diseases, PrP(c), a widely expressed protein, is transformed into a pathogenic form called PrP(Sc), which is in itself infectious. Antibodies directed against PrP(c) have been shown to inhibit PrP(c) to PrP(Sc) conversion in vitro and protect in vivo from disease. Other effectors with poten...

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Detalles Bibliográficos
Autores principales: Rosset, Martine Bruley, Sacquin, Antoine, Lecollinet, Sylvie, Chaigneau, Thomas, Adam, Micheline, Crespeau, François, Eloit, Marc
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/
https://www.ncbi.nlm.nih.gov/pubmed/19295917
http://dx.doi.org/10.1371/journal.pone.0004917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654673/
https://www.ncbi.nlm.nih.gov/pubmed/19295917
http://dx.doi.org/10.1371/journal.pone.0004917

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