Prediction of specificity-determining residues for small-molecule kinase inhibitors

BACKGROUND: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a given kinase will typically yield many compounds that inhibit more than one kinase. A series of chemical modifications are u...

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Detalles Bibliográficos
Autores principales: Caffrey, Daniel R, Lunney, Elizabeth A, Moshinsky, Deborah J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655090/
https://www.ncbi.nlm.nih.gov/pubmed/19032760
http://dx.doi.org/10.1186/1471-2105-9-491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655090/
https://www.ncbi.nlm.nih.gov/pubmed/19032760
http://dx.doi.org/10.1186/1471-2105-9-491

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