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Diene-modified nucleotides for the Diels–Alder-mediated functional tagging of DNA
We explore the potential of the Diels–Alder cycloaddition for the functional tagging of DNA strands. A deoxyuridine triphosphate derivative carrying a diene at position 5 of the pyrimidine base was synthesized using a two-step procedure. The derivative was efficiently accepted as substrate in enzyma...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655660/ https://www.ncbi.nlm.nih.gov/pubmed/19139071 http://dx.doi.org/10.1093/nar/gkn1066 |