Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes

When positioned opposite to a dA in a DNA duplex, the prototype arylamine–DNA adduct [N-(2′-deoxyguanosin-yl)-7-fluoro-2-aminofluorene (FAF)] adopts the so-called ‘wedge’ (W) conformation, in which the carcinogen resides in the minor groove of the duplex. All 16 FAF-modified 12-mer NG*N/NAN dA misma...

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Detalles Bibliográficos
Autores principales: Jain, Nidhi, Meneni, Srinivasarao, Jain, Vipin, Cho, Bongsup P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655675/
https://www.ncbi.nlm.nih.gov/pubmed/19151371
http://dx.doi.org/10.1093/nar/gkn1063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655675/
https://www.ncbi.nlm.nih.gov/pubmed/19151371
http://dx.doi.org/10.1093/nar/gkn1063

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