Cisplatin induces loop structures and condensation of single DNA molecules

Structural properties of single λ DNA treated with anti-cancer drug cisplatin were studied with magnetic tweezers and AFM. Under the effect of low-concentration cisplatin, the DNA became more flexible, with the persistence length decreased significantly from ∼52 to 15 nm. At a high drug concentratio...

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Detalles Bibliográficos
Autores principales: Hou, Xi-Miao, Zhang, Xing-Hua, Wei, Kong-Ji, Ji, Chao, Dou, Shuo-Xing, Wang, Wei-Chi, Li, Ming, Wang, Peng-Ye
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655688/
https://www.ncbi.nlm.nih.gov/pubmed/19129234
http://dx.doi.org/10.1093/nar/gkn933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655688/
https://www.ncbi.nlm.nih.gov/pubmed/19129234
http://dx.doi.org/10.1093/nar/gkn933

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