Influence of substituent modifications on the binding of 2-amino-1,8-naphthyridines to cytosine opposite an AP site in DNA duplexes: thermodynamic characterization

Here, we report on a significant effect of substitutions on the binding affinity of a series of 2-amino-1,8-naphthyridines, i.e., 2-amino-1,8-naphthyridine (AND), 2-amino-7-methyl-1,8-naphthyridine (AMND), 2-amino-5,7-dimethyl-1,8-naphthyridine (ADMND) and 2-amino-5,6,7-trimethyl-1,8-naphthyridine (...

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Detalles Bibliográficos
Autores principales: Sato, Yusuke, Nishizawa, Seiichi, Yoshimoto, Keitaro, Seino, Takehiro, Ichihashi, Toshiki, Morita, Kotaro, Teramae, Norio
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Chemistry and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655693/
https://www.ncbi.nlm.nih.gov/pubmed/19136458
http://dx.doi.org/10.1093/nar/gkn1079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655693/
https://www.ncbi.nlm.nih.gov/pubmed/19136458
http://dx.doi.org/10.1093/nar/gkn1079

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