Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

Binding to the CD4 receptor induces conformational changes in the human immunodeficiency virus (HIV-1) gp120 exterior envelope glycoprotein. These changes allow gp120 to bind the coreceptor, either CCR5 or CXCR4, and prime the gp41 transmembrane envelope glycoprotein to mediate virus–cell membrane f...

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Detalles Bibliográficos
Autores principales: Haim, Hillel, Si, Zhihai, Madani, Navid, Wang, Liping, Courter, Joel R., Princiotto, Amy, Kassa, Aemro, DeGrace, Marciella, McGee-Estrada, Kathleen, Mefford, Megan, Gabuzda, Dana, Smith, Amos B., Sodroski, Joseph
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655723/
https://www.ncbi.nlm.nih.gov/pubmed/19343205
http://dx.doi.org/10.1371/journal.ppat.1000360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655723/
https://www.ncbi.nlm.nih.gov/pubmed/19343205
http://dx.doi.org/10.1371/journal.ppat.1000360

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