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Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

Tuberous sclerosis complex (TSC) is an autosomal dominant, tumor predisposition disorder characterized by significant neurodevelopmental brain lesions, such as tubers and subependymal nodules. The neuropathology of TSC is often associated with seizures and intellectual disability. To learn about the...

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Detalles Bibliográficos
Autores principales: Way, Sharon W., McKenna, James, Mietzsch, Ulrike, Reith, R. Michelle, Wu, Henry Cheng-ju, Gambello, Michael J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655769/
https://www.ncbi.nlm.nih.gov/pubmed/19150975
http://dx.doi.org/10.1093/hmg/ddp025