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Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGFβ-1 in cultured rat nucleus pulposus cells

INTRODUCTION: Although transforming growth factor β1 (TGFβ1) is known to be a potent inhibitor of proliferation in most cell types, it accelerates proliferation in certain mesenchymal cells, such as articular chondrocytes and nucleus pulposus cells. The low ability for self-renewal of nucleus pulpos...

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Detalles Bibliográficos
Autores principales: Nakai, Tomoko, Mochida, Joji, Sakai, Daisuke
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656245/
https://www.ncbi.nlm.nih.gov/pubmed/19061498
http://dx.doi.org/10.1186/ar2567