Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

How oncogenes modulate the self-renewal properties of cancer-initiating cells is incompletely understood. Activating KRAS and NRAS mutations are among the most common oncogenic lesions detected in human cancer, and occur in myeloproliferative disorders (MPDs) and leukemias. We investigated the effec...

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Detalles Bibliográficos
Autores principales: Sabnis, Amit J, Cheung, Laurene S, Dail, Monique, Kang, Hio Chung, Santaguida, Marianne, Hermiston, Michelle L, Passegué, Emmanuelle, Shannon, Kevin, Braun, Benjamin S
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656550/
https://www.ncbi.nlm.nih.gov/pubmed/19296721
http://dx.doi.org/10.1371/journal.pbio.1000059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656550/
https://www.ncbi.nlm.nih.gov/pubmed/19296721
http://dx.doi.org/10.1371/journal.pbio.1000059

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