Focal Transplantation-based Astrocyte Replacement is Neuroprotective in a Model of Motor Neuron Disease

Cellular abnormalities in amyotrophic lateral sclerosis (ALS) are not limited to motor neurons. Astrocyte dysfunction occurs in human ALS and SOD1(G93A) animal models. Therefore, the value of focal enrichment of normal astrocytes was investigated using transplantation of lineage-restricted astrocyte...

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Detalles Bibliográficos
Autores principales: Lepore, Angelo C., Rauck, Britta, Dejea, Christine, Pardo, Andrea C., Rao, Mahendra S., Rothstein, Jeffrey D., Maragakis, Nicholas J.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656686/
https://www.ncbi.nlm.nih.gov/pubmed/18931666
http://dx.doi.org/10.1038/nn.2210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656686/
https://www.ncbi.nlm.nih.gov/pubmed/18931666
http://dx.doi.org/10.1038/nn.2210

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