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Allosteric Theory: Taking Therapeutic Advantage of the Malleable Nature of GPCRs
The description of the allosteric modification of receptors to affect changes in their function requires a model that considers the effects of the modulator on both agonist affinity and efficacy. A model is presented which describes changes in affinity in terms of the constant α (ratio of affinity i...
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| Formato: | Texto |
| Lenguaje: | English |
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Bentham Science Publishers Ltd.
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656818/ https://www.ncbi.nlm.nih.gov/pubmed/19305797 http://dx.doi.org/10.2174/157015907781695973 |