Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

BACKGROUND: Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as cross-tolerance to morphine. These effects are mediated by cannabinoids binding to peripheral, spinal and supraspinal CB1 and CB2 receptors, making it...

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Detalles Bibliográficos
Autores principales: Garzón, Javier, de la Torre-Madrid, Elena, Rodríguez-Muñoz, María, Vicente-Sánchez, Ana, Sánchez-Blázquez, Pilar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657119/
https://www.ncbi.nlm.nih.gov/pubmed/19284549
http://dx.doi.org/10.1186/1744-8069-5-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657119/
https://www.ncbi.nlm.nih.gov/pubmed/19284549
http://dx.doi.org/10.1186/1744-8069-5-11

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