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Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine
BACKGROUND: Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as cross-tolerance to morphine. These effects are mediated by cannabinoids binding to peripheral, spinal and supraspinal CB1 and CB2 receptors, making it...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657119/ https://www.ncbi.nlm.nih.gov/pubmed/19284549 http://dx.doi.org/10.1186/1744-8069-5-11 |