Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

A new, highly efficient, all-solid-phase synthesis of argifin, a natural product cyclic pentapeptide chitinase inhibitor, is reported. The synthesis features attachment of an orthogonally protected Asp residue to the solid support and assembly of the linear peptide chain by Fmoc SPPS prior to cyclis...

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Detalles Bibliográficos
Autores principales: Dixon, Mark J., Nathubhai, Amit, Andersen, Ole A., van Aalten, Daan M. F., Eggleston, Ian M.
Formato: Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2009
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657367/
https://www.ncbi.nlm.nih.gov/pubmed/19109670
http://dx.doi.org/10.1039/b815077j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657367/
https://www.ncbi.nlm.nih.gov/pubmed/19109670
http://dx.doi.org/10.1039/b815077j

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