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Glycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides

AIMS: High-density lipoprotein (HDL) protects against atherosclerosis development. Defective functioning of HDL in Type 2 diabetes may be one cause of increased cardiovascular disease associated with Type 2 diabetes. HDL modulates low-density lipoprotein and cell membrane oxidation through the actio...

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Detalles Bibliográficos
Autores principales: Mastorikou, M, Mackness, B, Liu, Y, Mackness, M
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659363/
https://www.ncbi.nlm.nih.gov/pubmed/18937674
http://dx.doi.org/10.1111/j.1464-5491.2008.02546.x