Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escap...

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Detalles Bibliográficos
Autores principales: Troyer, Ryan M., McNevin, John, Liu, Yi, Zhang, Shao Chong, Krizan, Randall W., Abraha, Awet, Tebit, Denis M., Zhao, Hong, Avila, Santiago, Lobritz, Michael A., McElrath, M. Juliana, Le Gall, Sylvie, Mullins, James I., Arts, Eric J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659432/
https://www.ncbi.nlm.nih.gov/pubmed/19343217
http://dx.doi.org/10.1371/journal.ppat.1000365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659432/
https://www.ncbi.nlm.nih.gov/pubmed/19343217
http://dx.doi.org/10.1371/journal.ppat.1000365

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