Cargando…

Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Troyer, Ryan M., McNevin, John, Liu, Yi, Zhang, Shao Chong, Krizan, Randall W., Abraha, Awet, Tebit, Denis M., Zhao, Hong, Avila, Santiago, Lobritz, Michael A., McElrath, M. Juliana, Le Gall, Sylvie, Mullins, James I., Arts, Eric J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659432/ https://www.ncbi.nlm.nih.gov/pubmed/19343217 http://dx.doi.org/10.1371/journal.ppat.1000365

Ejemplares similares

Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection
por: Liu, Yi, et al.
Publicado: (2011)

Similar Replicative Fitness Is Shared by the Subtype B and Unique BF Recombinant HIV-1 Isolates that Dominate the Epidemic in Argentina
por: Rubio, Andrea E., et al.
Publicado: (2014)

Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage
por: Nankya, Immaculate L, et al.
Publicado: (2015)

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release
por: Chan, Marina, et al.
Publicado: (2021)

CTL Escape and Viral Fitness in HIV/SIV Infection
por: Seki, Sayuri, et al.
Publicado: (2012)

HIV CTL escape: at what cost?
por: Smith, Stephen M
Publicado: (2004)

Virus escape from CTL recognition
Publicado: (1994)

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
por: Leslie, Alasdair, et al.
Publicado: (2005)

Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes
por: Leviyang, Sivan, et al.
Publicado: (2015)

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape
por: Dinter, Jens, et al.
Publicado: (2015)

Structured Observations Reveal Slow HIV-1 CTL Escape
por: Roberts, Hannah E., et al.
Publicado: (2015)

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
por: Carlson, Jonathan M., et al.
Publicado: (2008)

HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly
por: Reed, Jonathan C., et al.
Publicado: (2012)

P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication
por: Oniangue-Ndza, C, et al.
Publicado: (2009)

Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape
por: Karlsson, Annika C., et al.
Publicado: (2007)

CTL Escape Mediated by Proteasomal Destruction of an HIV-1 Cryptic Epitope
por: Cardinaud, Sylvain, et al.
Publicado: (2011)

Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection
por: Ganusov, Vitaly V, et al.
Publicado: (2006)

P09-18. Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
por: Honeyborne, I, et al.
Publicado: (2009)

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
por: Deng, Kai, et al.
Publicado: (2015)

Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape
por: Meyer-Olson, Dirk, et al.
Publicado: (2004)

HIV-1 Replication Fitness of HLA-B*57/58:01 CTL Escape Variants Is Restored by the Accumulation of Compensatory Mutations in Gag
por: Gijsbers, Esther F., et al.
Publicado: (2013)

Impact of transmitted CTL escape mutations on replicative capacity and HIV pathogenesis in early infection
por: Prince, J, et al.
Publicado: (2012)

OA06-03. Dynamics of CTL epitope escape and reversion in an African subtype C cohort
por: Schaefer, M, et al.
Publicado: (2009)

Within-Epitope Interactions Can Bias CTL Escape Estimation in Early HIV Infection
por: Garcia, Victor, et al.
Publicado: (2017)

Impact of Mutations in Highly Conserved Amino Acids of the HIV-1 Gag-p24 and Env-gp120 Proteins on Viral Replication in Different Genetic Backgrounds
por: Liu, Yi, et al.
Publicado: (2014)

Enrichment of intersubtype HIV-1 recombinants in a dual infection system using HIV-1 strain-specific siRNAs
por: Gao, Yong, et al.
Publicado: (2011)

Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage
por: Chopera, Denis R., et al.
Publicado: (2008)

A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens
por: Seidel, Ursula J. E., et al.
Publicado: (2011)

Emergent Electroweak Gravity
por: McElrath, Bob
Publicado: (2008)

Laboratory tests for the cosmic neutrino background using beta-decaying nuclei
por: McElrath, Bob
Publicado: (2009)

On The Origin of Neutrino Mass and Mixing in the Standard Model
por: McElrath, Bob
Publicado: (2009)

Use of adenovirus type-5 vectored vaccines: a cautionary tale
por: Buchbinder, Susan P, et al.
Publicado: (2020)

COVID-19 vaccination and HIV-1 acquisition – Authors’ reply
por: Buchbinder, Susan P, et al.
Publicado: (2022)

Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape Dynamics
por: Yang, Yiding, et al.
Publicado: (2018)

Forensic Autosomal Short Tandem Repeats and Their Potential Association With Phenotype
por: Wyner, Nicole, et al.
Publicado: (2020)

Maintenance of viral suppression in HIV-1–infected HLA-B*57(+) elite suppressors despite CTL escape mutations
por: Bailey, Justin R., et al.
Publicado: (2006)

$h \to \mu^{+}\mu^{-}$ via Gluon Fusion at the LHC
por: Han, T, et al.
Publicado: (2002)

A viral CTL escape mutation leading to immunoglobulin-like transcript 4–mediated functional inhibition of myelomonocytic cells
por: Lichterfeld, Mathias, et al.
Publicado: (2007)

There is no explosion risk associated with superfluid Helium in the LHC cooling system
por: Fairbairn, Malcolm, et al.
Publicado: (2008)

Bi-transgenic Mice Reveal that K-ras(Val12) Augments a p53-independent Apoptosis When Small Intestinal Villus Enterocytes Reenter the Cell Cycle
por: Coopersmith, Craig M., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_nbjfdbq4u5givmbqk6m0o18pt0