Enhanced Cancer Cell Growth Inhibition by Dipeptide Prodrugs of Floxuridine: Increased Transporter Affinity and Metabolic Stability

[Image: see text] Dipeptide monoester prodrugs of floxuridine were synthesized, and their chemical stability in buffers, resistance to glycosidic bond metabolism, affinity for PEPT1, enzymatic activation and permeability in cancer cells were determined and compared to those of mono amino acid monoes...

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Detalles Bibliográficos
Autores principales: Tsume, Yasuhiro, Hilfinger, John M., Amidon, Gordon L.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659690/
https://www.ncbi.nlm.nih.gov/pubmed/18652477
http://dx.doi.org/10.1021/mp800008c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659690/
https://www.ncbi.nlm.nih.gov/pubmed/18652477
http://dx.doi.org/10.1021/mp800008c

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