Inducible Transgenic Rat Model for Diabetes Mellitus Based on shRNA-Mediated Gene Knockdown

The rat is an important animal model in biomedical research, but gene targeting technology is not established for this species. Therefore, we aimed to produce transgenic knockdown rats using shRNA technology and pronuclear microinjection. To this purpose, we employed a tetracycline-inducible shRNA e...

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Detalles Bibliográficos
Autores principales: Kotnik, Katarina, Popova, Elena, Todiras, Mihail, Mori, Marcelo A., Alenina, Natalia, Seibler, Jost, Bader, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659743/
https://www.ncbi.nlm.nih.gov/pubmed/19340286
http://dx.doi.org/10.1371/journal.pone.0005124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659743/
https://www.ncbi.nlm.nih.gov/pubmed/19340286
http://dx.doi.org/10.1371/journal.pone.0005124

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