A Functional Screen for Regulators of CKDN2A Reveals MEOX2 as a Transcriptional Activator of INK4a

The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to identify novel transcriptional activators of...

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Detalles Bibliográficos
Autores principales: Irelan, Jeffrey T., Gutierrez del Arroyo, Ana, Gutierrez, Abel, Peters, Gordon, Quon, Kim C., Miraglia, Loren, Chanda, Sumit K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659797/
https://www.ncbi.nlm.nih.gov/pubmed/19340300
http://dx.doi.org/10.1371/journal.pone.0005067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659797/
https://www.ncbi.nlm.nih.gov/pubmed/19340300
http://dx.doi.org/10.1371/journal.pone.0005067

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