A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity

The liver stage of Plasmodium's life cycle is the first, obligatory step in malaria infection. Decreasing the hepatic burden of Plasmodium infection decreases the severity of disease and constitutes a promising strategy for malaria prophylaxis. The efficacy of the gamma-secretase and signal pep...

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Detalles Bibliográficos
Autores principales: Parvanova, Iana, Epiphanio, Sabrina, Fauq, Abdul, Golde, Todd E., Prudêncio, Miguel, Mota, Maria M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659798/
https://www.ncbi.nlm.nih.gov/pubmed/19337374
http://dx.doi.org/10.1371/journal.pone.0005078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659798/
https://www.ncbi.nlm.nih.gov/pubmed/19337374
http://dx.doi.org/10.1371/journal.pone.0005078

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