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Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins
Mitoxantrone is a potent antitumor drug, widely used in the treatment of various cancers. In the present study, we have investigated and compared the affinity of anticancer drug, mitoxantrone, to EDTA-soluble chromatin (SE-chromatin), DNA and histones employing UV/Vis, fluorescence, CD spectroscopy,...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660295/ https://www.ncbi.nlm.nih.gov/pubmed/19284573 http://dx.doi.org/10.1186/1423-0127-16-31 |