Real-Time Imaging of HIF-1α Stabilization and Degradation

HIF-1α is overexpressed in many human cancers compared to normal tissues due to the interaction of a multiplicity of factors and pathways that reflect specific genetic alterations and extracellular stimuli. We developed two HIF-1α chimeric reporter systems, HIF-1α/FLuc and HIF-1α(ΔODDD)/FLuc, to inv...

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Detalles Bibliográficos
Autores principales: Moroz, Ekaterina, Carlin, Sean, Dyomina, Katerina, Burke, Sean, Thaler, Howard T., Blasberg, Ronald, Serganova, Inna
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660410/
https://www.ncbi.nlm.nih.gov/pubmed/19347037
http://dx.doi.org/10.1371/journal.pone.0005077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660410/
https://www.ncbi.nlm.nih.gov/pubmed/19347037
http://dx.doi.org/10.1371/journal.pone.0005077

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