The Fas/FADD death domain complex structure unravels signaling by receptor clustering

The Death Inducing Signaling Complex (DISC) formed by Fas receptor, FADD and caspase-8 is a pivotal trigger of apoptosis1-3. The Fas/FADD DISC represents a receptor platform, which once assembled initiates the induction of programmed cell death. A highly oligomeric network of homotypic protein inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Scott, Fiona L., Stec, Boguslaw, Pop, Cristina, Dobaczewska, Małgorzata K., Lee, JeongEun J., Monosov, Edward, Robinson, Howard, Salvesen, Guy S., Schwarzenbacher, Robert, Riedl, Stefan J.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661029/
https://www.ncbi.nlm.nih.gov/pubmed/19118384
http://dx.doi.org/10.1038/nature07606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661029/
https://www.ncbi.nlm.nih.gov/pubmed/19118384
http://dx.doi.org/10.1038/nature07606

Ejemplares similares