Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

BACKGROUND: The expression and activity of P-glycoproteins due to genetic or environmental factors may have a significant impact on drug disposition, drug effectiveness or drug toxicity. Hence, characterization of drug disposition over a wide range of conditions of these membrane transporters activi...

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Detalles Bibliográficos
Autores principales: Fenneteau, Frédérique, Turgeon, Jacques, Couture, Lucie, Michaud, Véronique, Li, Jun, Nekka, Fahima
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661039/
https://www.ncbi.nlm.nih.gov/pubmed/19146691
http://dx.doi.org/10.1186/1742-4682-6-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661039/
https://www.ncbi.nlm.nih.gov/pubmed/19146691
http://dx.doi.org/10.1186/1742-4682-6-2

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