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Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

BACKGROUND: The expression and activity of P-glycoproteins due to genetic or environmental factors may have a significant impact on drug disposition, drug effectiveness or drug toxicity. Hence, characterization of drug disposition over a wide range of conditions of these membrane transporters activi...

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Detalles Bibliográficos
Autores principales:	Fenneteau, Frédérique, Turgeon, Jacques, Couture, Lucie, Michaud, Véronique, Li, Jun, Nekka, Fahima
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661039/ https://www.ncbi.nlm.nih.gov/pubmed/19146691 http://dx.doi.org/10.1186/1742-4682-6-2

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