Immunization with Radiation-Attenuated Plasmodium berghei Sporozoites Induces Liver cCD8α(+)DC that Activate CD8(+)T Cells against Liver-Stage Malaria

Immunization with radiation (γ)-attenuated Plasmodia sporozoites (γ-spz) confers sterile and long-lasting immunity against malaria liver-stage infection. In the P. berghei γ-spz model, protection is linked to liver CD8(+) T cells that express an effector/memory (T(EM)) phenotype, (CD44(hi)CD45RB(lo)...

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Detalles Bibliográficos
Autores principales: Jobe, Ousman, Donofrio, Gina, Sun, Guangping, Liepinsh, Dmitry, Schwenk, Robert, Krzych, Urszula
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661143/
https://www.ncbi.nlm.nih.gov/pubmed/19347042
http://dx.doi.org/10.1371/journal.pone.0005075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661143/
https://www.ncbi.nlm.nih.gov/pubmed/19347042
http://dx.doi.org/10.1371/journal.pone.0005075

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