Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance

Insulin/IGF-1 signaling (IIS) regulates development and metabolism, and modulates aging, of Caenorhabditis elegans. In nematodes, as in mammals, IIS is understood to operate through a kinase-phosphorylation cascade that inactivates the DAF-16/FOXO transcription factor. Situated at the center of this...

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Detalles Bibliográficos
Autores principales: Tazearslan, Çagdaþ, Ayyadevara, Srinivas, Bharill, Puneet, Shmookler Reis, Robert J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661368/
https://www.ncbi.nlm.nih.gov/pubmed/19360094
http://dx.doi.org/10.1371/journal.pgen.1000452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661368/
https://www.ncbi.nlm.nih.gov/pubmed/19360094
http://dx.doi.org/10.1371/journal.pgen.1000452

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