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Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance

Insulin/IGF-1 signaling (IIS) regulates development and metabolism, and modulates aging, of Caenorhabditis elegans. In nematodes, as in mammals, IIS is understood to operate through a kinase-phosphorylation cascade that inactivates the DAF-16/FOXO transcription factor. Situated at the center of this...

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Detalles Bibliográficos
Autores principales:	Tazearslan, Çagdaþ, Ayyadevara, Srinivas, Bharill, Puneet, Shmookler Reis, Robert J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661368/ https://www.ncbi.nlm.nih.gov/pubmed/19360094 http://dx.doi.org/10.1371/journal.pgen.1000452

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