β-Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform

OBJECTIVE: Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible liver-specific insulin receptor knockout mouse (iLIRKO). RESEARCH DESIGN AND METHODS:...

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Detalles Bibliográficos
Autores principales: Escribano, Oscar, Guillén, Carlos, Nevado, Carmen, Gómez-Hernández, Almudena, Kahn, C. Ronald, Benito, Manuel
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661585/
https://www.ncbi.nlm.nih.gov/pubmed/19136656
http://dx.doi.org/10.2337/db08-0551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661585/
https://www.ncbi.nlm.nih.gov/pubmed/19136656
http://dx.doi.org/10.2337/db08-0551

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