Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

Kinesin-3 motors drive the transport of synaptic vesicles and other membrane-bound organelles in neuronal cells. In the absence of cargo, kinesin motors are kept inactive to prevent motility and ATP hydrolysis. Current models state that the Kinesin-3 motor KIF1A is monomeric in the inactive state an...

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Detalles Bibliográficos
Autores principales: Hammond, Jennetta W, Cai, Dawen, Blasius, T. Lynne, Li, Zhe, Jiang, Yuyang, Jih, Gloria T, Meyhofer, Edgar, Verhey, Kristen J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661964/
https://www.ncbi.nlm.nih.gov/pubmed/19338388
http://dx.doi.org/10.1371/journal.pbio.1000072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661964/
https://www.ncbi.nlm.nih.gov/pubmed/19338388
http://dx.doi.org/10.1371/journal.pbio.1000072

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