PDGF-C Induces Maturation of Blood Vessels in a Model of Glioblastoma and Attenuates the Response to Anti-VEGF Treatment

BACKGROUND: Recent clinical trials of VEGF inhibitors have shown promise in the treatment of recurrent glioblastomas (GBM). However, the survival benefit is usually short-lived as tumors escape anti-VEGF therapies. Here we tested the hypothesis that Platelet Derived Growth Factor-C (PDGF-C), an isof...

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Detalles Bibliográficos
Autores principales: di Tomaso, Emmanuelle, London, Nyall, Fuja, Daniel, Logie, James, Tyrrell, James A., Kamoun, Walid, Munn, Lance L., Jain, Rakesh K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662415/
https://www.ncbi.nlm.nih.gov/pubmed/19352490
http://dx.doi.org/10.1371/journal.pone.0005123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662415/
https://www.ncbi.nlm.nih.gov/pubmed/19352490
http://dx.doi.org/10.1371/journal.pone.0005123

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