The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease

Impairment of the ubiquitin-proteasome system (UPS) has long been considered an attractive hypothesis to explain the selective dysfunction and death of neurons in polyglutamine disorders such as Huntington's disease (HD). The fact that inclusion bodies in HD mouse models and patient brains are...

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Detalles Bibliográficos
Autores principales: Bett, John S., Cook, Casey, Petrucelli, Leonard, Bates, Gillian P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662425/
https://www.ncbi.nlm.nih.gov/pubmed/19352500
http://dx.doi.org/10.1371/journal.pone.0005128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662425/
https://www.ncbi.nlm.nih.gov/pubmed/19352500
http://dx.doi.org/10.1371/journal.pone.0005128

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