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Tumor Associated Stromal Cells Play a Critical Role on the Outcome of the Oncolytic Efficacy of Conditionally Replicative Adenoviruses

The clinical efficacy of conditionally replicative oncolytic adenoviruses (CRAd) is still limited by the inefficient infection of the tumor mass. Since tumor growth is essentially the result of a continuous cross-talk between malignant and tumor-associated stromal cells, targeting both cell compartm...

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Detalles Bibliográficos
Autores principales: Lopez, M. Verónica, Viale, Diego L., Cafferata, Eduardo G. A., Bravo, Alicia I., Carbone, Cecilia, Gould, David, Chernajovsky, Yuti, Podhajcer, Osvaldo L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663040/
https://www.ncbi.nlm.nih.gov/pubmed/19337591
http://dx.doi.org/10.1371/journal.pone.0005119