Negative Smad Expression and Regulation in the Developing Chick Limb

The inhibitory or negative Smads, Smad6 and Smad7, block TGFβ superfamily signals of both the BMP and TGFβ classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation...

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Detalles Bibliográficos
Autores principales: Vargesson, Neil, Laufer, Ed
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663054/
https://www.ncbi.nlm.nih.gov/pubmed/19352514
http://dx.doi.org/10.1371/journal.pone.0005173
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author Vargesson, Neil
Laufer, Ed
author_facet Vargesson, Neil
Laufer, Ed
author_sort Vargesson, Neil
collection PubMed
description The inhibitory or negative Smads, Smad6 and Smad7, block TGFβ superfamily signals of both the BMP and TGFβ classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in limb mesenchyme indicates that negative Smad gene expression is regulated, at least in part, by BMP family signals.
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spelling pubmed-26630542009-04-08 Negative Smad Expression and Regulation in the Developing Chick Limb Vargesson, Neil Laufer, Ed PLoS One Research Article The inhibitory or negative Smads, Smad6 and Smad7, block TGFβ superfamily signals of both the BMP and TGFβ classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in limb mesenchyme indicates that negative Smad gene expression is regulated, at least in part, by BMP family signals. Public Library of Science 2009-04-08 /pmc/articles/PMC2663054/ /pubmed/19352514 http://dx.doi.org/10.1371/journal.pone.0005173 Text en Vargesson, Laufer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Vargesson, Neil
Laufer, Ed
Negative Smad Expression and Regulation in the Developing Chick Limb
title Negative Smad Expression and Regulation in the Developing Chick Limb
title_full Negative Smad Expression and Regulation in the Developing Chick Limb
title_fullStr Negative Smad Expression and Regulation in the Developing Chick Limb
title_full_unstemmed Negative Smad Expression and Regulation in the Developing Chick Limb
title_short Negative Smad Expression and Regulation in the Developing Chick Limb
title_sort negative smad expression and regulation in the developing chick limb
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663054/
https://www.ncbi.nlm.nih.gov/pubmed/19352514
http://dx.doi.org/10.1371/journal.pone.0005173
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