Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways

BACKGROUND: Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and cyclin-dependent kinase inhibitors p21 and p27 remain unclear. METHODS: Normal human lung fibroblasts (NHLF) were c...

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Detalles Bibliográficos
Autores principales: Mizuno, Shiro, Bogaard, Herman J, Voelkel, Norbert F, Umeda, Yukihiro, Kadowaki, Maiko, Ameshima, Shingo, Miyamori, Isamu, Ishizaki, Takeshi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663549/
https://www.ncbi.nlm.nih.gov/pubmed/19267931
http://dx.doi.org/10.1186/1465-9921-10-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663549/
https://www.ncbi.nlm.nih.gov/pubmed/19267931
http://dx.doi.org/10.1186/1465-9921-10-17

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