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Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways

BACKGROUND: Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and cyclin-dependent kinase inhibitors p21 and p27 remain unclear. METHODS: Normal human lung fibroblasts (NHLF) were c...

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Detalles Bibliográficos
Autores principales:	Mizuno, Shiro, Bogaard, Herman J, Voelkel, Norbert F, Umeda, Yukihiro, Kadowaki, Maiko, Ameshima, Shingo, Miyamori, Isamu, Ishizaki, Takeshi
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663549/ https://www.ncbi.nlm.nih.gov/pubmed/19267931 http://dx.doi.org/10.1186/1465-9921-10-17

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