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Amyloidogenesis Abolished by Proline Substitutions but Enhanced by Lipid Binding
The influence of lipid molecules on the aggregation of a highly amyloidogenic segment of human islet amyloid polypeptide, hIAPP20–29, and the corresponding sequence from rat has been studied by all-atom replica exchange molecular dynamics (REMD) simulations with explicit solvent model. hIAPP20–29 fr...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663790/ https://www.ncbi.nlm.nih.gov/pubmed/19360098 http://dx.doi.org/10.1371/journal.pcbi.1000357 |