A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow

INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage...

Descripción completa

Detalles Bibliográficos
Autores principales: Madhyastha, Sampath, Prabhu, Latha V, Saralaya, V, Rai, Rajalakshmi
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664285/
https://www.ncbi.nlm.nih.gov/pubmed/19061007
http://dx.doi.org/10.1590/S1807-59322008000600019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664285/
https://www.ncbi.nlm.nih.gov/pubmed/19061007
http://dx.doi.org/10.1590/S1807-59322008000600019

Ejemplares similares