Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo

Conditionally replicative adenoviruses (CRAds) represent a novel treatment strategy for malignant glioma. Recent studies suggest that the cytopathic effect elicited by these vectors is mediated through autophagy, a form of programmed cell death. Likewise, temozolomide (TMZ), a chemotherapeutic agent...

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Detalles Bibliográficos
Autores principales: Ulasov, I V, Sonabend, A M, Nandi, S, Khramtsov, A, Han, Y, Lesniak, M S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664399/
https://www.ncbi.nlm.nih.gov/pubmed/19277041
http://dx.doi.org/10.1038/sj.bjc.6604969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664399/
https://www.ncbi.nlm.nih.gov/pubmed/19277041
http://dx.doi.org/10.1038/sj.bjc.6604969

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