Successful Expansion but Not Complete Restriction of Tropism of Adeno-Associated Virus by In Vivo Biopanning of Random Virus Display Peptide Libraries

Targeting viral vectors to certain tissues in vivo has been a major challenge in gene therapy. Cell type-directed vector capsids can be selected from random peptide libraries displayed on viral capsids in vitro but so far this system could not easily be translated to in vivo applications. Using a no...

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Detalles Bibliográficos
Autores principales: Michelfelder, Stefan, Kohlschütter, Johannes, Skorupa, Alexandra, Pfennings, Sabrina, Müller, Oliver, Kleinschmidt, Jürgen A., Trepel, Martin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664470/
https://www.ncbi.nlm.nih.gov/pubmed/19357785
http://dx.doi.org/10.1371/journal.pone.0005122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664470/
https://www.ncbi.nlm.nih.gov/pubmed/19357785
http://dx.doi.org/10.1371/journal.pone.0005122

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