Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched (Ptch1), but it is unclear if ciliary traffickin...

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Detalles Bibliográficos
Autores principales: Wilson, Christopher W., Chen, Miao-Hsueh, Chuang, Pao-Tien
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664476/
https://www.ncbi.nlm.nih.gov/pubmed/19365551
http://dx.doi.org/10.1371/journal.pone.0005182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664476/
https://www.ncbi.nlm.nih.gov/pubmed/19365551
http://dx.doi.org/10.1371/journal.pone.0005182

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