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Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin

One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions. We present a conceptual framework that explains how this requirement causes the probability that a particular amino acid mutation is fixed during ev...

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Detalles Bibliográficos
Autores principales: Bloom, Jesse D., Glassman, Matthew J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664478/
https://www.ncbi.nlm.nih.gov/pubmed/19381264
http://dx.doi.org/10.1371/journal.pcbi.1000349