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Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions. We present a conceptual framework that explains how this requirement causes the probability that a particular amino acid mutation is fixed during ev...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664478/ https://www.ncbi.nlm.nih.gov/pubmed/19381264 http://dx.doi.org/10.1371/journal.pcbi.1000349 |