A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry

[Image: see text] Biomolecules labeled with azides can be detected through Cu-free click chemistry with cyclooctyne probes, but their intrinsic hydrophobicity can compromise bioavailability. Here, we report the synthesis and evaluation of a novel azacyclooctyne, 6,7-dimethoxyazacyclooct-4-yne (DIMAC...

Descripción completa

Detalles Bibliográficos
Autores principales: Sletten, Ellen M., Bertozzi, Carolyn R.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664610/
https://www.ncbi.nlm.nih.gov/pubmed/18549231
http://dx.doi.org/10.1021/ol801141k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664610/
https://www.ncbi.nlm.nih.gov/pubmed/18549231
http://dx.doi.org/10.1021/ol801141k

Ejemplares similares