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A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry
[Image: see text] Biomolecules labeled with azides can be detected through Cu-free click chemistry with cyclooctyne probes, but their intrinsic hydrophobicity can compromise bioavailability. Here, we report the synthesis and evaluation of a novel azacyclooctyne, 6,7-dimethoxyazacyclooct-4-yne (DIMAC...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664610/ https://www.ncbi.nlm.nih.gov/pubmed/18549231 http://dx.doi.org/10.1021/ol801141k |